MORPHINE GLUCURONYLTRANSFERASE Meaning and
Definition
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Morphine Glucuronyltransferase is a specific enzyme that plays a crucial role in the metabolism of morphine, a powerful opioid analgesic drug. This enzyme belongs to the glucuronyltransferase family and is primarily responsible for the enzymatic process called glucuronidation, which is a major metabolic pathway of xenobiotic substances in the human body.
Glucuronidation is a phase II metabolic reaction that primarily occurs in the liver and involves the attachment of a glucuronic acid molecule to the substrate, in this case, morphine. Morphine Glucuronyltransferase facilitates this glucuronidation process by catalyzing the transfer of glucuronic acid from the coenzyme UDP-glucuronic acid to morphine. This conjugation reaction results in the formation of morphine-3-glucuronide, which is a water-soluble metabolite that can be easily eliminated from the body.
The activity and expression of Morphine Glucuronyltransferase can vary among individuals due to genetic factors, leading to inter-individual variability in the metabolism and clearance of morphine. These variations can influence the effectiveness and safety of morphine therapy since it affects the duration and intensity of its pharmacological effects. Moreover, alterations in Morphine Glucuronyltransferase activity can impact the accumulation of morphine metabolites, which may contribute to differences in drug toxicity and adverse effects.
Understanding the function and regulation of Morphine Glucuronyltransferase is important for optimizing individualized drug therapy involving morphine and related opioids, as well as for enhancing the safety and efficacy of pain management strategies.
Common Misspellings for MORPHINE GLUCURONYLTRANSFERASE
- norphine glucuronyltransferase
- korphine glucuronyltransferase
- jorphine glucuronyltransferase
- mirphine glucuronyltransferase
- mkrphine glucuronyltransferase
- mlrphine glucuronyltransferase
- mprphine glucuronyltransferase
- m0rphine glucuronyltransferase
- m9rphine glucuronyltransferase
- moephine glucuronyltransferase
- modphine glucuronyltransferase
- mofphine glucuronyltransferase
- motphine glucuronyltransferase
- mo5phine glucuronyltransferase
- mo4phine glucuronyltransferase
- morohine glucuronyltransferase
- morlhine glucuronyltransferase
- mor-hine glucuronyltransferase
- mor0hine glucuronyltransferase
- morpgine glucuronyltransferase
Etymology of MORPHINE GLUCURONYLTRANSFERASE
The word "Morphine Glucuronyltransferase" consists of three parts: "morphine", "glucuronyl", and "transferase".
1. Morphine: The word "morphine" comes from the Greek word "morphina" (μορφίνη). It was coined by Friedrich Wilhelm Adam Sertürner, a German pharmacist, in 1817. Sertürner derived the name from Morpheus, the Greek god of dreams, because of the drug's sedative properties.
2. Glucuronyl: The term "glucuronyl" is derived from "glucuronic acid", which is a sugar acid. "Glucuronic" is a combination of "gluco-" meaning "glucose" and "-uronic" indicating the presence of a uronic acid residue.
