MHC RESTRICTION Meaning and
Definition
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MHC restriction, also known as major histocompatibility complex restriction, refers to the phenomenon in the immune system where immune cells specifically recognize and respond to foreign antigens presented by the MHC molecules on the surface of host cells. The MHC molecules, also called human leukocyte antigen (HLA) in humans, are a group of cell surface proteins crucial for the immune system's ability to recognize self from non-self.
In the context of MHC restriction, immune cells, such as T lymphocytes, possess receptors called T cell receptors (TCRs) that can specifically recognize and bind to antigenic peptides presented by MHC molecules. This recognition is critical for the activation of T cells and subsequent immune response. Each individual has a diverse set of MHC molecules encoded by multiple genes, resulting in a wide range of antigen presentation capabilities.
The restriction aspect of MHC restriction refers to the fact that T cells can only recognize and bind to antigenic peptides when they are presented by MHC molecules that are compatible with their specific TCRs. This compatibility is determined by the unique genetic variants of MHC molecules and TCRs in each individual.
MHC restriction is a fundamental principle governing immune recognition and response. It ensures that immune cells target foreign antigens specifically and effectively while maintaining tolerance to self-antigens. The ability of MHC molecules to bind and present a wide array of antigens allows the immune system to mount a diverse and adaptable defense against pathogens.
Common Misspellings for MHC RESTRICTION
- nhc restriction
- khc restriction
- jhc restriction
- mgc restriction
- mbc restriction
- mnc restriction
- mjc restriction
- muc restriction
- myc restriction
- mhx restriction
- mhv restriction
- mhf restriction
- mhd restriction
- mhc eestriction
- mhc destriction
- mhc festriction
- mhc testriction
- mhc 5estriction
- mhc 4estriction
- mhc rwstriction
Etymology of MHC RESTRICTION
The term "MHC restriction" refers to the specific recognition and interaction between the major histocompatibility complex (MHC) molecules and T-cell receptors (TCR) in the immune system. The etymology of the term "MHC restriction" can be broken down as follows:
1. Major Histocompatibility Complex (MHC): The term "histocompatibility" originates from the Greek words "histos", meaning tissue, and "compatible", meaning to be harmonious or well-suited. It was initially used to describe the compatibility or lack thereof between tissues when transplanted between individuals. The major histocompatibility complex itself was discovered in the mid-20th century through studies of graft rejection in mice and subsequent experiments on tissue transplantation.
2. Restriction: The term "restriction" derives from the Latin word "restrictio", which means to limit, bound, or confine.
