METHYLTRANSFERASE PIMT Meaning and
Definition
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Methyltransferase PIMT (Protein L-isoaspartate (D-aspartate) O-methyltransferase) is an enzyme that plays a crucial role in the maintenance of protein integrity and function in various organisms, including humans. It is involved in a post-translational modification process known as methylation, where a methyl group is added to specific amino acids in proteins.
The primary function of Methyltransferase PIMT is to repair damaged or improperly formed proteins. During protein synthesis or aging processes, spontaneous conversion of L-isoaspartate to D-aspartate can occur due to asparagine (a specific amino acid) deamidation or isomerization. This conversion can lead to structural changes in the proteins, affecting their stability and function. Methyltransferase PIMT plays a critical role in reversing this conversion, restoring the damaged proteins back to their original form.
The enzyme achieves this by transferring a methyl group to the D-aspartate or L-isoaspartate residues in proteins, thereby converting them back to L-aspartate. This methylation process repairs the damaged proteins and prevents their aggregation or degradation, ensuring their proper folding and functionality.
Methyltransferase PIMT has been implicated in various biological processes, including DNA repair, regulation of gene expression, and cellular response to stress. Dysfunction or deficiency in this enzyme can lead to protein misfolding, accumulation of damaged proteins, and subsequent development of various health conditions, such as neurodegenerative diseases.
Overall, Methyltransferase PIMT is an essential enzyme involved in the repair and maintenance of protein integrity, critical for proper cellular function and human health.
Common Misspellings for METHYLTRANSFERASE PIMT
- methyltransferasepiemt
- m ethyltransferase pimt
- me thyltransferase pimt
- met hyltransferase pimt
- meth yltransferase pimt
- methy ltransferase pimt
- methyl transferase pimt
- methylt ransferase pimt
- methyltr ansferase pimt
- methyltra nsferase pimt
- methyltran sferase pimt
- methyltrans ferase pimt
- methyltransf erase pimt
- methyltransfe rase pimt
- methyltransfer ase pimt
- methyltransfera se pimt
- methyltransferas e pimt
- methyltransferase pi mt
- methyltransferase pim t
Etymology of METHYLTRANSFERASE PIMT
The word "Methyltransferase PIMT" has its etymology as follows:
1. Methyltransferase: The term "methyltransferase" originated from the combination of two words:
- "Methyl" comes from the Greek word "methy" which means wine or spirits. This is because methyl groups are often derived from methane, which is found in natural gas and can be produced during fermentation, such as the fermentation of wine.
- "Transferase" comes from the Latin word "transferre" which means "to carry across". In the context of enzymes, transferases catalyze the transfer of functional groups (such as methyl groups) from one molecule to another.
2. PIMT: The term "PIMT" is an acronym for Peptidyl-prolyl cis-trans isomerase, also known as Protein L-isoaspartate O-methyltransferase.
