How Do You Spell METHYLENETETRAHYDROFOLATE DEHYDROGENASE?

Pronunciation: [mˈɛθa͡ɪlnˌɛtɪtɹˌɑːɹa͡ɪdɹˌɒfəlˌe͡ɪt dˌiːha͡ɪdɹˈə͡ʊd͡ʒne͡ɪs] (IPA)

The spelling of "Methylenetetrahydrofolate Dehydrogenase" can be quite a mouthful. The word is pronounced as /mɛθəlinətɛtrəhaɪdroʊfoʊleɪt diːhaɪdroʊdʒəneɪz/ in IPA phonetic transcription, which helps in understanding the pronunciation. The long word refers to an enzyme that plays a crucial role in the metabolism of folate or folic acid. Though it may be difficult to spell or say, this enzyme is vital for proper cellular function and is essential for human health.

Meaning and Definition
Common Misspellings
Etymology
Basic Check Advanced Check

METHYLENETETRAHYDROFOLATE DEHYDROGENASE Meaning and Definition

  1. Methylenetetrahydrofolate Dehydrogenase, also known as MTHFD1 (Methylenetetrahydrofolate dehydrogenase 1), is an enzyme that plays a crucial role in the folate metabolism pathway. It is involved in the conversion of methylenetetrahydrofolate (MTHF) to methyltetrahydrofolate (MTHF), an essential step in the synthesis of purines, pyrimidines, and the methylation of molecules such as DNA and proteins.

    MTHFD1 is a multifunctional enzyme, possessing dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase activities. The dehydrogenase activity catalyzes the conversion of MTHF to MTHF, while the cyclohydrolase activity is responsible for the hydrolysis of 5,10-methenyltetrahydrofolate (MTHF) into 5,10-methylenetetrahydrofolate (5,10-MTHF).

    The enzyme is crucial for the proper functioning and balance of folate metabolism, which is essential for various cellular processes, including DNA synthesis, repair, and methylation. Disruptions or deficiencies in MTHFD1 activity can lead to dysregulation of folate metabolism, resulting in pathological conditions such as megaloblastic anemia, cardiovascular diseases, and neural tube defects in newborns.

    Methylenetetrahydrofolate Dehydrogenase is a target for therapeutic interventions, and its inhibition has been explored as a potential strategy in cancer treatment due to its role in rapidly dividing cancer cells. Inhibitors of MTHFD1

Common Misspellings for METHYLENETETRAHYDROFOLATE DEHYDROGENASE

  • nethylenetetrahydrofolate dehydrogenase
  • kethylenetetrahydrofolate dehydrogenase
  • jethylenetetrahydrofolate dehydrogenase
  • mwthylenetetrahydrofolate dehydrogenase
  • msthylenetetrahydrofolate dehydrogenase
  • mdthylenetetrahydrofolate dehydrogenase
  • mrthylenetetrahydrofolate dehydrogenase
  • m4thylenetetrahydrofolate dehydrogenase
  • m3thylenetetrahydrofolate dehydrogenase
  • merhylenetetrahydrofolate dehydrogenase
  • mefhylenetetrahydrofolate dehydrogenase
  • meghylenetetrahydrofolate dehydrogenase
  • meyhylenetetrahydrofolate dehydrogenase
  • me6hylenetetrahydrofolate dehydrogenase
  • me5hylenetetrahydrofolate dehydrogenase
  • metgylenetetrahydrofolate dehydrogenase
  • metbylenetetrahydrofolate dehydrogenase
  • metnylenetetrahydrofolate dehydrogenase
  • metjylenetetrahydrofolate dehydrogenase
  • metuylenetetrahydrofolate dehydrogenase

Etymology of METHYLENETETRAHYDROFOLATE DEHYDROGENASE

The word "Methylenetetrahydrofolate Dehydrogenase" is composed of several components:

1. Methylenetetrahydrofolate: "Methylene" refers to a compound containing a divalent carbon atom with two single bonds to two different atoms. "Tetrahydrofolate" refers to a form of the B-vitamin folate that contains four hydrogen atoms and a conjugated ring structure.

2. Dehydrogenase: "Dehydrogenase" is derived from the Greek words "dehydrós" (meaning "lacking water") and "génos" (meaning "birth" or "origin"). "Dehydrogenase" refers to an enzyme that removes hydrogen atoms from a substrate during a chemical reaction.