The spelling of the word Methoxone can be explained using the International Phonetic Alphabet (IPA). The IPA phonetic transcription for Methoxone is /mɛθɑksəʊn/. The first syllable 'Meth-' is pronounced as 'Meth' with a short "e" and "th" sound. The second syllable '-ox-' is pronounced as 'ocks' with a short "o" and "ks" sound. The final syllable '-one' is pronounced as 'own' with an "ow" sound. Methoxone is a synthetic opioid used for pain management and addiction treatment.