METALLOTHIONEIN I Meaning and
Definition
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Metallothionein I (MT-I) is a small protein encoded by the MT-1 gene that plays a crucial role in the regulation of metal ions within living organisms. It is part of a family of metal-binding proteins known as metallothioneins, which are highly conserved across species.
MT-I exhibits a high affinity for binding metal ions, especially heavy metals such as zinc, copper, and cadmium. It acts as an important buffer and mediator for the proper functioning and homeostasis of these metals in various biological systems. MT-I can be found in different tissues and organs, including the liver, kidney, brain, and lungs.
One of the distinguishing features of MT-I is its ability to induce synthesis under conditions of metal overload or stress. Elevated metal concentrations trigger the activation of the MT-1 gene, leading to increased production of Metallothionein I. This upregulation helps to sequester and detoxify excess metal ions, preventing their harmful effects on cellular structures and processes. Furthermore, MT-I is involved in maintaining the balance between essential metals and protecting against oxidative stress caused by reactive oxygen species.
The biological functions of Metallothionein I are diverse and multifaceted. It has been linked to metal homeostasis, protection against heavy metal toxicity, and has shown antioxidant and anti-inflammatory properties. The expression and activity of MT-I have also been associated with various diseases, such as cancer, neurodegenerative disorders, and cardiovascular conditions.
In summary, Metallothionein I is a small protein that serves as a crucial player in the regulation of metal ions within organisms. Its main role is to maintain metal homeostasis, protect against metal toxicity, and provide antioxidant defense.
Common Misspellings for METALLOTHIONEIN I
- netallothionein i
- ketallothionein i
- jetallothionein i
- mwtallothionein i
- mstallothionein i
- mdtallothionein i
- mrtallothionein i
- m4tallothionein i
- m3tallothionein i
- merallothionein i
- mefallothionein i
- megallothionein i
- meyallothionein i
- me6allothionein i
- me5allothionein i
- metzllothionein i
- metsllothionein i
- metwllothionein i
- metqllothionein i
- metaklothionein i
Etymology of METALLOTHIONEIN I
The word "Metallothionein I" is a combination of several terms: "metallothionein" and the Roman numeral "I".
The term "metallothionein" combines "metal" and "thionein". "Metal" refers to the type of substance, usually a chemical element, that can donate electrons to form positive ions. "Thionein" refers to a small protein that binds to metals and contains thiol (-SH) groups.
The Roman numeral "I" denotes that "Metallothionein I" is the first variant or isoform of the metallothionein protein. Roman numerals are often used to distinguish between different versions or copies of a particular protein.
