How Do You Spell MEGALOBLAST?

Pronunciation: [mˈɛɡəlˌɒblast] (IPA)

The word "megaloblast" is spelled with three syllables and pronounced as /ˈmɛɡ.ə.loʊ.blæst/. The first syllable starts with the "m" sound, followed by the "eh" sound, and ends with the "g" sound. The second syllable starts with the "uh" sound, followed by the "low" sound, and ends with the "b" sound. The final syllable starts with the "l" sound, followed by the "a" sound, and ends with the "s" and "t" sounds. The word is commonly used in medicine referring to a large abnormal cell.

MEGALOBLAST Meaning and Definition

1. A megaloblast can be defined as an abnormal, large, and immature red blood cell precursor characterized by an enlarged nucleus. It is typically found in the bone marrow and has distinct morphological features differentiating it from normal erythroblasts. The term "megaloblast" is derived from the Greek words "mega" meaning large and "blastos" meaning bud or precursor.

   In hematological contexts, megaloblasts are primarily associated with certain medical conditions, most notably megaloblastic anemia. This type of anemia is characterized by the presence of megaloblasts in the bone marrow, caused by impaired division and maturation of erythroblasts. Megaloblastic anemia is commonly caused by deficiencies in vitamin B12 and/or folic acid, essential nutrients for healthy red blood cell production.

   The identification of megaloblasts is facilitated through microscopic examination of blood samples or bone marrow specimens. These cells typically exhibit larger than normal size (macrocytosis) and an abnormally high nuclear-cytoplasmic ratio. The nucleus of a megaloblast is often round or oval-shaped and presents abnormalities in chromatin pattern and nuclear segmentation. Many megaloblasts also contain characteristic inclusions called Howell-Jolly bodies, which are remnants of chromosomal material.

   Overall, the identification of megaloblasts serves as an important diagnostic characteristic in understanding and diagnosing various hematological disorders.

2. A large nucleated red blood corpuscle, or primitive erythroblast.

   A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

Common Misspellings for MEGALOBLAST

• negaloblast
• kegaloblast
• jegaloblast
• mwgaloblast
• msgaloblast
• mdgaloblast
• mrgaloblast
• m4galoblast
• m3galoblast
• mefaloblast
• mevaloblast
• mebaloblast
• mehaloblast
• meyaloblast
• metaloblast
• megzloblast
• megsloblast
• megwloblast
• megqloblast

Etymology of MEGALOBLAST

The word "megaloblast" is derived from two Greek roots: "megas" meaning large or great, and "blastos" meaning immature or embryonic cell. The term specifically refers to abnormally large red blood cells found in certain medical conditions.

Similar spelling words for MEGALOBLAST

• megalopolis,
• megaloblastic,
• mescal bean,
• megaloptera,
• megalohepatia.

Plural form of MEGALOBLAST is MEGALOBLASTS