How Do You Spell MEGALIN?

Pronunciation: [mˈɛɡəlˌɪn] (IPA)

The word megalin (/ˈmɛɡəlɪn/) appears quite straightforward at first, but its spelling actually follows some interesting phonetic rules. The "e" in the first syllable is pronounced as a short "e" sound, while the "a" in the second syllable is pronounced as a short "uh" sound. Additionally, the stress falls on the second syllable, hence why the "a" is pronounced more prominently than the "e". Megalin is a protein found in the kidneys, and its name reflects its size and importance in the body.

MEGALIN Meaning and Definition

1. Megalin is a transmembrane glycoprotein receptor that plays a crucial role in the process of endocytosis, particularly in the reabsorption of filtered proteins by kidney cells. It is a large protein receptor found on the epithelial cells lining the renal tubules and has also been identified in various other tissues, including the liver, lungs, and intestines.

   The primary function of megalin is to facilitate the internalization of proteins that have been filtered by the glomerulus of the kidney. It acts as a receptor, binding to specific proteins and allowing their uptake into the cell through clathrin-mediated endocytosis. By recognizing and transporting proteins, megalin contributes to the regulation of essential processes such as protein homeostasis and nutrient recycling.

   In addition to its role in protein reabsorption, megalin has been implicated in various other functions. It has been shown to participate in the cellular uptake of vitamins, hormones, lipoproteins, and other molecules. Furthermore, megalin is believed to play a vital role in embryonic development, as loss of its function in animal models has been associated with severe developmental abnormalities.

   Overall, megalin is a critical receptor involved in the endocytic process, particularly in the context of protein reabsorption by kidney cells. Its multifunctionality and widespread presence in various tissues underscore its significance in several physiological processes.

Common Misspellings for MEGALIN

• negalin
• kegalin
• jegalin
• mwgalin
• msgalin
• mdgalin
• mrgalin
• m4galin
• m3galin
• mefalin
• mevalin
• mebalin
• mehalin
• meyalin
• megzlin
• megslin
• megwlin
• megqlin
• megapin
• megaoin

Etymology of MEGALIN

The word "Megalin" has a scientific etymology. It is derived from the Greek prefix "mega-", meaning large or great, and the Latin word "linum", meaning thread. "Megalin" refers to a large receptor protein found in the kidneys, known for its crucial role in the reabsorption of proteins from the urine back into the bloodstream.