MEASLES FUSION PROTEIN Meaning and
Definition
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Measles fusion protein is a term used in the field of virology and immunology to refer to a specific viral protein derived from the measles virus (MeV). The measles fusion protein plays a crucial role in the viral infection process. It is responsible for mediating the fusion of the viral envelope with the host cell membrane, which enables the virus to enter and infect the host cell.
The measles fusion protein is a transmembrane protein that is located on the surface of the viral envelope. It consists of two subunits – the F1 protein and the F2 protein, which are produced as a single polypeptide chain that undergoes proteolytic cleavage to generate the mature and functional fusion protein. The F1 subunit contains the fusion peptide, a hydrophobic region critical for membrane fusion, while the F2 subunit is responsible for receptor binding.
Upon contact with host cells, the conformational changes of the measles fusion protein are triggered, leading to the exposure of the fusion peptide. This facilitates the binding of the fusion protein to specific receptors on the host cell surface, promoting the fusion of the viral envelope with the cell membrane. This fusion event allows the viral genome to enter the host cell, initiating the viral replication process.
Understanding the structure and function of the measles fusion protein is essential for the development of treatments and preventive strategies against measles infection. Targeting this protein could potentially provide opportunities for the development of antiviral drugs and vaccines to control measles outbreaks and reduce the associated morbidity and mortality.
Common Misspellings for MEASLES FUSION PROTEIN
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