MAXIMUM TOLERATED DOSES Meaning and
Definition
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Maximum tolerated dose (MTD) refers to the highest amount or concentration of a substance or treatment that an organism or individual can withstand without experiencing intolerable side effects or toxicity. It is commonly used in the field of toxicology and clinical trials to determine the safe dosage levels of drugs, chemicals, or radiation that can be given to individuals without resulting in severe adverse reactions.
In toxicology studies, MTD is determined through a series of escalating doses administered to a group of test subjects, typically animals. Starting with a low concentration, the dosage is gradually increased until the maximum tolerated dose is reached. This dose is usually defined as the level at which toxic effects, such as organ damage or behavioral changes, become unacceptable or life-threatening.
MTD is also crucial in assessing the safety and efficacy of experimental drugs during clinical trials. In these trials, a range of dosage levels is tested in human volunteers to identify the highest dose that can be tolerated without causing severe harm. It helps researchers and physicians to establish the most effective therapeutic dose that balances the desired treatment outcome with acceptable adverse effects.
Determining the maximum tolerated dose is essential for ensuring the safety of individuals exposed to potentially harmful substances or undergoing experimental treatments. By accurately determining this threshold, researchers and clinicians can mitigate the risk of adverse reactions and make informed decisions regarding dosage recommendations in order to maximize the treatment's benefit while minimizing harm.
Common Misspellings for MAXIMUM TOLERATED DOSES
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