MAXIMALLY TOLERATED DOSE Meaning and
Definition
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Maximally Tolerated Dose (MTD) is a term commonly used in medical and pharmaceutical disciplines to define the highest dosage of a drug or treatment that a patient can tolerate without experiencing unacceptable or intolerable side effects.
In clinical trials and medical research, MTD is determined through a stepwise approach wherein patients are administered increasing doses of a particular drug until either toxicity or adverse effects begin to manifest. The MTD is then identified as the highest dose level at which these side effects are considered acceptable and manageable for the majority of patients.
The objective of determining the MTD is primarily to establish the optimal dosage for a therapeutic agent, striking a balance between efficacy and safety. Finding the MTD involves careful evaluation and assessment of multiple factors, including the drug's pharmacology, physiological response, and individual patient characteristics such as age, weight, and overall health.
The MTD determination is crucial in developing treatment guidelines, prescribing instructions, and dosage recommendations for medical professionals. It provides critical information for establishing proper dosing regimens in clinical practice, ensuring that patients receive an effective and safe level of treatment while minimizing the risk of adverse reactions. Notably, the MTD may vary between different patient populations, highlighting the need for customized dosing strategies based on individual patient profiles.
Common Misspellings for MAXIMALLY TOLERATED DOSE
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