MAPT Meaning and
Definition
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MAPT stands for microtubule-associated protein tau, which is a critical protein found in the human brain. It is primarily involved in stabilizing microtubules, which are responsible for maintaining the structural integrity and proper functioning of nerve cells. Tau proteins act as binders, facilitating the assembly and stability of microtubules in a healthy brain.
In a neurological context, MAPT is especially significant due to its association with various neurodegenerative disorders, most notably Alzheimer's disease (AD). In AD, abnormal clumps of tau protein accumulate in the brain, leading to the formation of twisted tangles known as neurofibrillary tangles. These tangles disrupt the normal functions of nerve cells and impede communication between them. The accumulation and spread of tau pathology are considered hallmark features of AD and are closely linked to the cognitive decline experienced by affected individuals.
Research on MAPT and its relationship with neurodegenerative diseases is an active field, as scientists strive to understand its role in disease progression and identify potential therapeutic targets. Various genetic mutations in the MAPT gene have been identified as risk factors for certain neurodegenerative disorders, highlighting the importance of this protein in maintaining brain health.
In summary, MAPT refers to the microtubule-associated protein tau, a crucial protein involved in stabilizing microtubules in the brain. It plays a significant role in various neurodegenerative diseases, particularly Alzheimer's disease, where abnormal tau protein accumulation leads to the formation of neurofibrillary tangles and subsequent cognitive impairment.
Common Misspellings for MAPT
- mzapt
- mazpt
- mwapt
- mawpt
- mqapt
- maqpt
- ma0pt
- map0t
- mapft
- mapyt
- map6t
- mapt6
- mmapt
- m apt
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