MAPKK Meaning and
Definition
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MAPKK, which stands for Mitogen-Activated Protein Kinase Kinase, is a crucial component of the intracellular signal transduction pathway known as the MAPK pathway. This protein kinase acts as an intermediary molecule between the upstream MAPKKK (Mitogen-Activated Protein Kinase Kinase Kinase) and the downstream MAPK (Mitogen-Activated Protein Kinase), transmitting signals from the cell surface to the nucleus.
The primary function of MAPKK is to phosphorylate and activate MAPK by catalyzing the transfer of a phosphate group from ATP to the target amino acid residues of MAPK. This phosphorylation event triggers a cascade of phosphorylation reactions that ultimately lead to the activation of various transcription factors and the regulation of gene expression. As a result, MAPKK plays a critical role in diverse cellular processes such as proliferation, differentiation, apoptosis, and response to extracellular stimuli including growth factors, stress signals, and cytokines.
The MAPKK protein family consists of multiple isoforms, each showing specificity towards different MAPKs and cellular stimuli. Some well-known MAPKK isoforms include MEK1 (MAPK/ERK kinase 1) and MEK2 (MAPK/ERK kinase 2), which are mainly involved in the activation of the ERK pathway. Other isoforms like MKK3 and MKK6 participate in the activation of stress-activated MAPKs like p38 and JNK, which are involved in cellular responses to environmental stressors.
Overall, MAPKK acts as a vital regulatory protein in cellular signaling networks, transmitting external signals to the nucleus and modulating cellular responses to various stimuli.
Common Misspellings for MAPKK
- nmapkk
- mmapkk
- maapkk
- mappkk
- mapkkk
- eAPKK
- iAPKK
- oAPKK
- lAPKK
- MiPKK
- MePKK
- McPKK
- MAxKK
- MAtKK
- MAqKK
- MAPcK
- MAPKc
- m apkk
- mapk k
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