MALATE SYNTHASE Meaning and
Definition
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Malate synthase is an enzyme that plays a vital role in cellular metabolism, specifically in the glyoxylate cycle. It is responsible for catalyzing the reversible condensation of acetyl-CoA and glyoxylate, forming malate and CoA. The glyoxylate cycle is found in certain microorganisms, plants, and other organisms and serves as an alternative pathway in situations where glucose is limited or unavailable.
Malate synthase is composed of two subunits: alpha and beta. The alpha subunit contains the active site, where the acetyl-CoA and glyoxylate bind and undergo the condensation reaction. The beta subunit, on the other hand, provides structural stability and assists in the correct folding of the enzyme. Together, these subunits work in coordination to efficiently carry out the catalysis of malate synthase.
In addition to its role in the glyoxylate cycle, malate synthase has also been found to participate in other metabolic pathways. It has been identified in certain bacteria to be involved in the assimilation of acetate and other carbon sources. This versatility highlights the importance of malate synthase in various metabolic processes.
Understanding the function and structure of malate synthase is crucial for further comprehension of cellular metabolism and its regulation. It provides essential insights into the adaptive mechanisms of organisms under different physiological conditions and can be targeted for potential therapeutic interventions in certain diseases.
Common Misspellings for MALATE SYNTHASE
- nalate synthase
- kalate synthase
- jalate synthase
- mzlate synthase
- mslate synthase
- mwlate synthase
- mqlate synthase
- makate synthase
- mapate synthase
- maoate synthase
- malzte synthase
- malste synthase
- malwte synthase
- malqte synthase
- malare synthase
- malafe synthase
- malage synthase
- malaye synthase
- mala6e synthase
- mala5e synthase
Etymology of MALATE SYNTHASE
The word "Malate Synthase" has its etymology rooted in the field of biochemistry and is derived from two components: "malate" and "synthase".
1. Malate:
The term "malate" is derived from the Latin word "malum", which means apple. It originally referred to the acidic taste found in the juice and pulp of apples. The name "malate" was given to a specific organic compound called malic acid, which is abundant in apples, and is linked to its sour taste. Malic acid plays a vital role in cellular metabolism and is commonly found in various fruits and vegetables in addition to apples.
2. Synthase:
The term "synthase" is derived from the Greek word "synthēsis", which means composition or putting together.
