Macronormoblast is a medical term used to describe a large precursor cell in the blood that gives rise to red blood cells. The spelling of this word is broken down as follows: "ma-kroh-nor-moh-blast." Each syllable is pronounced as follows: /ˈmeɪ.krɒn/ /ˈnɔː.məʊ/ /blæst/. The word contains a combination of Greek and Latin roots. "Makros" means "large" in Greek, while "normo" and "blast" come from the Latin "norma" (meaning "standard") and "blasta" (meaning "bud" or "sprout"), respectively.
A macronormoblast is a term predominantly used in the field of hematology to indicate the stage of a developing red blood cell, also known as an erythroblast. It represents an intermediate phase in erythropoiesis, the process by which new red blood cells are produced in the bone marrow. Macronormoblast specifically refers to the maturity level and characteristics of the cell at this particular stage.
The term "macronormoblast" can be broken down to its individual components: "macro-" meaning large or bigger, "normo-" denoting a normal or regular state, and "-blast" referring to an immature precursor cell. Therefore, a macronormoblast is a relatively larger-sized erythroblast that exhibits normal characteristics with regard to its shape, structure, and other key features.
In morphological terms, a macronormoblast is typically larger in size compared to an average red blood cell, featuring a round nucleus that occupies a substantial portion of the cell's cytoplasm. This stage is known to occur during the erythropoietic process after the phase of pronormoblast, preceding the production of reticulocytes, and eventually mature red blood cells.
The identification of macronormoblasts is crucial in the diagnosis of certain blood disorders, such as megaloblastic anemia, where abnormalities in red blood cell development can occur. Hematologists and other medical professionals utilize microscopic examination of blood smears to identify and differentiate various erythroblast stages, macronormoblast being one of them.
Macroerythroblast.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "macronormoblast" is composed of two distinct components: "macro-" and "normoblast".
1. "Macro-" is a prefix derived from the Greek word "makros", meaning "large" or "long". In English, this prefix is commonly used to denote something of larger size or scale.
2. "Normoblast" is a term used in the field of medicine to refer to a specific type of immature red blood cell. It consists of two parts: "nomo-" and "-blast".
- "Nomo-" is derived from the Greek word "nomos", meaning "law" or "custom", and in this context, it refers to normal or standard conditions.