Lometopane, also known as (−)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (β-CCT), is a chemical compound classified as a tropane derivative. It is a selective radioligand employed in scientific research to study the dopamine transporter (DAT).
The dictionary definition of lometopane entails its chemical structure as well as its specific function in scientific investigations. The compound's chemical formula consists of carbon, hydrogen, oxygen, and chlorine atoms. Lometopane belongs to the tropane class of compounds, which are characterized by a bicyclo[3.2.1]octane framework. The molecular structure of lometopane features a carbomethoxy group attached to the 2β position, a chlorine atom attached to the para position of the phenyl ring at the 3β position, and a tropane ring system.
The primary usage of lometopane is as a radioligand to examine the dopamine transporter – a protein responsible for the reuptake of dopamine from the synaptic cleft, consequently regulating dopamine transmission. Scientists utilize lometopane, combined with various radioisotopes, to label dopamine transporters in order to investigate their distribution, quantification, and affinity in living organisms. Through binding to the dopamine transporter, lometopane enables the visualization and analysis of dopamine transporter activity, facilitating the understanding of neurotransmission processes associated with dopamine.
Overall, lometopane serves as a valuable compound in scientific research to advance knowledge on the dopamine transporter system and its implications in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and addiction.
