Correct spelling for the English word "LOEL" is [lˈə͡ʊl], [lˈəʊl], [l_ˈəʊ_l] (IPA phonetic alphabet).
LOEL stands for Lowest-Observed-Effect Level. It is a term primarily used in toxicology and risk assessment to indicate the lowest concentration or amount of a substance that produces an observed adverse effect on living organisms.
The LOEL is determined through experimentation and is a critical parameter for assessing the potential harm of various substances to humans and other organisms. It is usually determined by conducting controlled studies in which different concentrations or doses of a substance are administered to test subjects. Researchers then observe the subjects for any adverse effects, such as physiological changes, organ damage, or behavioral abnormalities.
The LOEL is significant in risk assessment, as it helps establish safe exposure limits or guidelines for substances. This information is particularly relevant in industries involving chemical products, food safety, or environmental control. By determining the LOEL, scientists and regulators can set permissible exposure limits or develop safety standards to protect human health and the environment from harmful substances.
It is important to note that LOEL is distinct from the No-Observed-Effect Level (NOEL), which represents the highest concentration or dose at which no adverse effects are observed. The distinction between the two is critical for determining safe exposure levels and minimizing potential harm.