LLNA Meaning and
Definition
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LLNA stands for Local Lymph Node Assay. It is a laboratory test used in the field of toxicology and dermatology to assess the potential of a substance to cause allergic contact dermatitis. Allergic contact dermatitis is a type of skin inflammation resulting from an allergic reaction upon exposure to certain substances, known as allergens.
The LLNA is an alternative method to animal testing, primarily performed on mice. It aims to determine the sensitizing potential of a substance by measuring the proliferation of lymphocytes, cells involved in the body's immune response, in the lymph nodes following exposure. The test is based on the principle that skin sensitization occurs due to the activation and proliferation of lymphocytes.
During the LLNA, the test substance is applied to the skin of mice, typically on the ears or back. The mice are then sacrificed, and their lymph nodes are collected and processed to assess the level of lymphocyte proliferation. This evaluation is typically performed using techniques such as flow cytometry or incorporation of radioactive isotopes.
The LLNA is considered a reliable and validated method for identifying sensitizers and classifying their potency. It provides information on the potential hazard of a substance and aids in determining appropriate safety measures. The use of this assay helps reduce the need for animal experimentation and is an important tool in ensuring the safety and well-being of humans and animals exposed to various substances.
Common Misspellings for LLNA
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- LLfA
- LLNc
- l lna
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- lln a
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