LIVER MICROSOMES Meaning and
Definition
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Liver microsomes refer to subcellular components derived from liver cells, specifically the endoplasmic reticulum. Microsomes are isolated by a process called differential centrifugation, which involves breaking open liver cells and separating various cellular components based on their density. The resulting microsomes are composed predominantly of small vesicles originating from the endoplasmic reticulum.
Microsomes contain various enzymes responsible for drug metabolism, particularly those involved in phase I reactions. These enzymes, collectively known as cytochrome P450 enzymes, are essential for the biotransformation and elimination of xenobiotic substances, such as drugs and toxins, from the body. Liver microsomes are widely used in drug discovery and toxicity studies as they mimic the metabolic processes that occur in the human liver.
Furthermore, liver microsomes can be employed to determine the metabolic stability of drug candidates, predict potential drug-drug interactions, and investigate the mechanisms of drug metabolism. They provide a valuable in vitro tool to assess how drugs may be metabolized and cleared in the human body. Additionally, microsomes can serve as a platform for studying enzyme kinetics and drug metabolism pathways.
In conclusion, liver microsomes are subcellular components derived from liver cells that play a crucial role in drug metabolism. They contain enzymes responsible for the biotransformation of drugs and toxins, making them a valuable tool in drug discovery and toxicity studies.
Common Misspellings for LIVER MICROSOMES
- kiver microsomes
- piver microsomes
- oiver microsomes
- luver microsomes
- ljver microsomes
- lkver microsomes
- lover microsomes
- l9ver microsomes
- l8ver microsomes
- licer microsomes
- liber microsomes
- liger microsomes
- lifer microsomes
- livwr microsomes
- livsr microsomes
- livdr microsomes
- livrr microsomes
- liv4r microsomes
- liv3r microsomes
- livee microsomes
Etymology of LIVER MICROSOMES
The word "Liver" originates from the Old English word "lifere", which is derived from the Proto-Germanic word "librin" and the Indo-European root word "leip", meaning "body", "life", or "organ". In this context, it refers to the organ responsible for many vital functions in the human body.
The term "Microsomes" is a combination of two Greek words. "Micros" is derived from "mikros", meaning "small", and "soma" means "body" or "organism". In biology, "Microsome" was initially used to describe small cellular structures or components. It later evolved to refer specifically to subcellular particles derived from the endoplasmic reticulum during laboratory fractionation procedures.
