Lipotropin C Fragment is a peptide hormone that is an essential component of the melanocortin pathway. It is derived from the precursor protein proopiomelanocortin (POMC), which is then processed to form smaller peptide fragments. Lipotropin C Fragment, also known as alpha-melanocyte-stimulating hormone (-MSH), consists of the amino acid sequence 131-150 of POMC.
Lipotropin C Fragment has been found to have various biological functions, including regulation of appetite and energy homeostasis. It acts by binding to melanocortin receptors located in the brain, specifically the MC3R and MC4R receptors, which are involved in controlling feeding behavior and metabolism.
Additionally, Lipotropin C Fragment is known to have potent anti-inflammatory and immune-modulatory effects. It has been shown to suppress the production of pro-inflammatory molecules and promote the release of anti-inflammatory cytokines. This activity is mediated by its interaction with receptors found in immune cells, such as macrophages.
In the context of lipolysis, Lipotropin C Fragment has been implicated in the breakdown of stored fatty acids for energy production. It stimulates the release of triglycerides from adipose tissue by activating lipolytic pathways.
Overall, Lipotropin C Fragment plays a crucial role in regulating energy balance, inflammation, and lipid metabolism. Its potential therapeutic applications range from appetite control and weight management to modulation of immune responses and inflammation.
