LINEAR GRAMICIDIN Meaning and
Definition
-
Linear gramicidin is a peptide antibiotic that consists of a chain of alternating amino acids, primarily composed of the amino acids L-valine, D-leucine, L-leucine, and D-phenylalanine. It is known for its strong antimicrobial properties against various types of bacteria, making it an effective therapeutic agent against certain bacterial infections.
This peptide antibiotic is unique in its structure and mode of action. It forms channels or pores in the bacterial lipid bilayer, primarily in the cell membrane. These channels allow the passage of ions such as potassium and protons, disrupting the electrical potential across the cell membrane and leading to the death of the bacteria.
The linear gramicidin molecule has been extensively studied due to its ability to self-assemble into organized structures, such as helical bundles. These helical bundles are stabilized by hydrogen bonds between adjacent peptide chains and contribute to the formation of the ion channels.
Linear gramicidin has shown efficacy against a wide range of Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes. However, its activity against Gram-negative bacteria is limited due to the complex outer membrane structure of these bacteria, which inhibits the formation of the necessary channels.
Due to its potent antimicrobial properties and unique mode of action, linear gramicidin has gained attention in the field of drug development, particularly in the design of novel antibiotics and antimicrobial peptides.
Common Misspellings for LINEAR GRAMICIDIN
- kinear gramicidin
- pinear gramicidin
- oinear gramicidin
- lunear gramicidin
- ljnear gramicidin
- lknear gramicidin
- lonear gramicidin
- l9near gramicidin
- l8near gramicidin
- libear gramicidin
- limear gramicidin
- lijear gramicidin
- lihear gramicidin
- linwar gramicidin
- linsar gramicidin
- lindar gramicidin
- linrar gramicidin
- lin4ar gramicidin
- lin3ar gramicidin
- linezr gramicidin
Etymology of LINEAR GRAMICIDIN
The word "Linear Gramicidin" has its etymology derived from the Greek and Latin languages.
- "Linear" is derived from the Latin word "linearis", which means "of or pertaining to a line". In this context, it is used to describe the structure of the gramicidin molecule, which forms a linear arrangement.
- "Gramicidin" is a compound word consisting of two roots: "gramin-" and "-cidin". "Gramin-" comes from the Latin word "gramineus", meaning "of grass", while "-cidin" comes from the Latin "caedere", meaning "to kill". The term was originally coined by the scientists Robert B. Woodward and Pat Robert in 1944 to describe a group of antibiotic peptides derived from the soil bacteria Bacillus brevis, which were effective against many gram-positive bacteria.
