Large cell lymphoma is a type of cancer that affects the lymphatic system, which is part of the body's immune system. It is classified as a non-Hodgkin lymphoma, meaning it originates from the lymphatic cells and is not specific to Hodgkin's disease.
Large cell lymphoma is characterized by the presence of large abnormal cells in the lymph nodes, bone marrow, or other organs. These abnormal cells, known as lymphocytes, are larger than normal and can grow and divide rapidly, leading to the formation of tumors.
This type of lymphoma is further divided into different subtypes based on the appearance of the abnormal cells and other specific characteristics. The subtypes include diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMBCL), and anaplastic large cell lymphoma (ALCL), among others.
The exact cause of large cell lymphoma is still unknown, but certain risk factors have been identified, such as a weakened immune system, human immunodeficiency virus (HIV) infection, exposure to certain chemicals and toxins, and certain genetic mutations.
The symptoms of large cell lymphoma may include enlarged lymph nodes, fever, night sweats, fatigue, unexplained weight loss, and recurrent infections.
Treatment options for large cell lymphoma depend on various factors, including the subtype, stage of the disease, and overall health of the patient. Common treatment approaches may include chemotherapy, radiation therapy, targeted therapy, immunotherapy, and, in some cases, stem cell transplantation. Early detection and prompt treatment can significantly improve the prognosis and overall outcome for individuals with large cell lymphoma.
