Lamellipodias (IPA: ləˌmɛlɪˈpəʊdiˌæs) is a scientific term used to describe the thin, sheet-like extensions on the surface of cells that help with movement and other functions. The word is derived from the root word lamellipodia, which refers to these extensions, and the suffix -ias, which is used to denote a group or collection. The spelling of the word is based on its Greek origin, with "lamella" meaning "thin plate" and "podia" meaning "feet". With its complex spelling and pronunciation, Lamellipodias is a challenging word for many to master.
Lamellipodias (singular: lamellipodia) are thin, sheet-like protrusions found in the cell membrane of eukaryotic cells, particularly in animal cells. Lamellipodias are highly dynamic structures that play a crucial role in various cellular processes, such as cell motility, migration, and adhesion.
These structures consist of a network of actin filaments arranged in a branched fashion. Actin is a protein that polymerizes and depolymerizes to provide structural support and can undergo rapid assembly and disassembly to drive cellular movements. The branching of actin filaments in lamellipodias is facilitated by proteins known as ARP2/3 (Actin-related protein 2/3) complexes, which promote actin filament nucleation and elongation.
Lamellipodias are commonly observed at the leading edge of moving cells, where they extend and contract to facilitate cell migration and the exploration of the surrounding environment. The protrusion and retraction of lamellipodias contribute to the amoeboid movement of cells, allowing them to change their shape and direction of movement.
Furthermore, lamellipodias are involved in cell adhesion and the formation of focal adhesions. Focal adhesions are sites of attachment between the cell and the extracellular matrix, and they provide mechanical stability during cell migration and tissue organization.
Overall, lamellipodias are key structures in cell locomotion and tissue morphogenesis, allowing cells to navigate their environment, sense cues, and respond appropriately to external stimuli.
The word "lamellipodia" is derived from Latin and Greek roots.
The term "lamella" comes from Latin, meaning "a small, thin plate or blade". In biology, a lamella refers to a thin, flat structure or membrane found in various organisms.
The term "podos" comes from the Greek word "pous", meaning "foot". In biology, "pedia" or "podia" refers to a structure resembling or functioning as a foot.
So, when combined, "lamellipodia" refers to the thin, flat projections extending from the surface of certain cells that resemble feet. These structures are used for cell movement, especially in processes like crawling, migration, and wound healing.