L ISOASPARTYL PROTEIN CARBOXYMETHYLTRANSFERASE Meaning and
Definition
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L Isoaspartyl Protein Carboxymethyltransferase is an enzymatic protein that plays a crucial role in the maintenance of protein integrity and function within the human body. Also known as L-PIMT or PCMT1 (Protein L-Isoaspartate (D-Aspartate) O-Methyltransferase 1), it is responsible for the repair and regulation of isoaspartyl-containing proteins.
Isoaspartyl residues, formed spontaneously through the non-enzymatic deamidation and isomerization of asparagine and aspartate residues in proteins, can contribute to protein misfolding, aggregation, and dysfunction. L Isoaspartyl Protein Carboxymethyltransferase acts as a methyltransferase, catalyzing the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the β-carboxyl group of these abnormal isoaspartyl residues.
Through this enzymatic process, L Isoaspartyl Protein Carboxymethyltransferase converts isoaspartyl residues back to the normal aspartyl form, thereby preventing their accumulation and promoting protein stability. This activity is crucial for sustaining the structural and functional integrity of various proteins, including enzyme catalysis, cellular signaling, and immune response.
A deficiency or impairment in L Isoaspartyl Protein Carboxymethyltransferase activity has been associated with age-related diseases such as Alzheimer's and Parkinson's, as well as autoimmune disorders. Understanding the function and regulation of L Isoaspartyl Protein Carboxymethyltransferase provides insights into the mechanisms underlying protein quality control and the pathogenesis of these diseases.
Common Misspellings for L ISOASPARTYL PROTEIN CARBOXYMETHYLTRANSFERASE
- k isoaspartyl protein carboxymethyltransferase
- p isoaspartyl protein carboxymethyltransferase
- o isoaspartyl protein carboxymethyltransferase
- l usoaspartyl protein carboxymethyltransferase
- l jsoaspartyl protein carboxymethyltransferase
- l ksoaspartyl protein carboxymethyltransferase
- l osoaspartyl protein carboxymethyltransferase
- l 9soaspartyl protein carboxymethyltransferase
- l 8soaspartyl protein carboxymethyltransferase
- l iaoaspartyl protein carboxymethyltransferase
- l izoaspartyl protein carboxymethyltransferase
- l ixoaspartyl protein carboxymethyltransferase
- l idoaspartyl protein carboxymethyltransferase
- l ieoaspartyl protein carboxymethyltransferase
- l iwoaspartyl protein carboxymethyltransferase
- l isiaspartyl protein carboxymethyltransferase
- l iskaspartyl protein carboxymethyltransferase
- l islaspartyl protein carboxymethyltransferase
- l ispaspartyl protein carboxymethyltransferase
- l is0aspartyl protein carboxymethyltransferase
