KYNURENINE FORMAMIDASE Meaning and
Definition
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Kynurenine formamidase is an enzyme that plays a crucial role in the metabolism of tryptophan, an essential amino acid. It is encoded by the KYNU gene and is found in various species, including humans. This enzyme facilitates the conversion of kynurenine, an intermediate metabolite of tryptophan, into formamidopyruvate, another intermediate compound in the kynurenine pathway.
The kynurenine pathway is an important metabolic pathway involved in the degradation of tryptophan and the synthesis of various bioactive molecules. Kynurenine formamidase specifically acts on kynurenine, which can be derived from tryptophan through enzymatic processes. By catalyzing the transformation of kynurenine into formamidopyruvate, this enzyme contributes to the overall regulation and balance of the kynurenine pathway.
The activity of kynurenine formamidase has implications in various biological processes and diseases. It has been associated with immune responses, inflammation, neurotransmission, and the production of neuroactive metabolites. Dysregulation of the kynurenine pathway, including abnormalities in kynurenine formamidase activity, has been linked to neurodegenerative disorders, psychiatric conditions, and cancer development.
Scientists and researchers study kynurenine formamidase to better understand its role in physiological processes and diseases. The characterization of this enzyme's structure, function, and regulation provides valuable insights into potential therapeutic targets and strategies for the treatment and management of various disorders associated with the kynurenine pathway.
Common Misspellings for KYNURENINE FORMAMIDASE
- jynurenine formamidase
- mynurenine formamidase
- lynurenine formamidase
- oynurenine formamidase
- iynurenine formamidase
- ktnurenine formamidase
- kgnurenine formamidase
- khnurenine formamidase
- kunurenine formamidase
- k7nurenine formamidase
- k6nurenine formamidase
- kyburenine formamidase
- kymurenine formamidase
- kyjurenine formamidase
- kyhurenine formamidase
- kynyrenine formamidase
- kynhrenine formamidase
- kynjrenine formamidase
- kynirenine formamidase
- kyn8renine formamidase
Etymology of KYNURENINE FORMAMIDASE
The word "Kynurenine Formamidase" can be broken down into two parts: "kynurenine" and "formamidase".
1. Kynurenine:
The word "kynurenine" comes from the amino acid called "kynurenine". The term "kynurenine" itself originates from the Greek word "kynourenin" (κυνουρείν), which means "to cause a dog's urine". It was named as such because the compound was first isolated from the urine of dogs. Additionally, "kynurenine" is formed from the combination of two Greek roots: "κύων" (kyon) meaning "dog" and "ουρον" (ouron) meaning "urine".
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