Correct spelling for the English word "krebbs" is [kɹˈɛbz], [kɹˈɛbz], [k_ɹ_ˈɛ_b_z] (IPA phonetic alphabet).
Krebbs, also known as the Krebbs cycle or citric acid cycle, is a complex biochemical pathway involved in the process of cellular respiration. Named after its discoverer, Sir Hans Krebbs, this cycle is a crucial component of aerobic metabolism, occurring in the mitochondria of eukaryotic cells. It plays a fundamental role in the production of energy by breaking down carbohydrates, fats, and proteins.
The Krebbs cycle is a series of enzymatic reactions that generate high-energy compounds, mainly adenosine triphosphate (ATP), which acts as the primary source of energy within cells. It begins with the production of acetyl-CoA, derived from the breakdown of glucose during glycolysis, and then proceeds through a series of chemical reactions that involve the conversion of acetyl-CoA into several intermediate molecules, such as citrate, alpha-ketoglutarate, succinate, fumarate, and malate.
Throughout this cycle, electrons and hydrogen ions are released and ultimately transferred to the electron transport chain, another part of cellular respiration, to generate a flow of protons and synthesize ATP. In addition to energy production, the Krebbs cycle also plays a vital role in the synthesis of certain amino acids and other molecules required for cell function.
Understanding the Krebbs cycle is crucial in various fields, including biochemistry, physiology, and medicine, as its dysregulation can lead to various metabolic disorders and diseases.