Korean Hemorrhagic Fever Virus, also known as Hantaan virus, is a member of the Hantavirus genus, which belongs to the Bunyaviridae family. It is the causative agent of Korean hemorrhagic fever (KHF), a severe and often fatal disease that primarily affects humans. This virus was first identified in the 1970s during an outbreak in Korea.
Korean Hemorrhagic Fever Virus is predominantly transmitted to humans through contact with infected rodents, particularly the brown or Norway rat, and occasionally through inhalation of aerosolized rodent excreta. This virus is endemic in East Asia, particularly in rural and agricultural areas, where human contact with infected rodents is more frequent.
Upon infection, the virus enters the human body and primarily targets endothelial cells, causing damage to blood vessels as well as disturbances in blood clotting mechanisms. The symptoms of KHF typically include fever, headache, abdominal pain, and hemorrhagic manifestations, such as petechiae, ecchymosis, and bleeding from various sites. In severe cases, organ failure, shock, and even death can occur.
Currently, there are no specific antiviral treatments available for KHF caused by Korean Hemorrhagic Fever Virus. Supportive care, such as maintenance of fluid balance and symptom relief, is the mainstay of treatment. Preventive measures focusing on rodent control, proper hygiene, and avoidance of contact with rodent excreta are essential in reducing the risk of infection.
