Kimura disease is a rare, chronic inflammatory disorder of unknown cause that predominantly affects young adult males of Asian descent, particularly those of Chinese or Japanese ancestry. This condition is characterized by painless, tumor-like swellings in the lymph nodes of the head and neck region, most commonly in the parotid and submandibular regions. It is named after Mikizo Kimura, a Japanese pathologist who first described the disease in 1948.
The exact etiology of Kimura disease remains uncertain, but it is believed to be an immune-mediated disorder involving an abnormal immune response to an unknown antigen. Some research suggests that it may be associated with an allergic or hypersensitivity reaction. The hallmark histological characteristic is the presence of dense, eosinophilic infiltrates, along with varying degrees of lymphoid hyperplasia.
The clinical presentation of Kimura disease typically includes painless, soft tissue swellings in the lymph nodes, which may gradually enlarge over time and become palpable. The affected areas may also experience discomfort, itching, and a sense of fullness. Other possible symptoms include skin involvement, such as dermatitis or nodular lesions, as well as proteinuria and eosinophilia in some cases.
Diagnosis of Kimura disease involves a combination of clinical evaluation, imaging studies (e.g., ultrasound or MRI), and histopathological examination of tissue samples obtained through biopsy. Treatment typically involves a multidisciplinary approach, including surgical excision of the affected lymph nodes, along with medications such as corticosteroids, immunosuppressants, and antiallergic drugs.
Overall, Kimura disease is a rare, chronic inflammatory disorder characterized by painless, tumor-like swellings in the lymph nodes of the head and neck region. While it primarily affects young
