The Ki ras gene, also known as KRAS (Kirsten rat sarcoma viral oncogene homolog), is a gene responsible for coding a protein involved in cell signaling pathways. It is an oncogene, meaning it has the potential to cause cancer when altered or mutated.
The KRAS gene is found in humans and encodes the KRAS protein, which is a small GTPase enzyme involved in transmitting signals from the cell surface to the cell nucleus. This protein plays a crucial role in the regulation of cell growth and differentiation. When the KRAS gene becomes mutated, it can lead to the constant activation of the KRAS protein, causing uncontrolled cell division and proliferation.
Mutations in the KRAS gene are commonly found in various types of cancers, particularly colorectal, lung, and pancreatic cancers. The KRAS gene mutation is often associated with a poor prognosis and resistance to certain cancer therapies.
Understanding the status of the KRAS gene in a tumor is crucial in determining treatment options. Genetic testing can identify specific mutations in the KRAS gene, which helps guide personalized therapies and predict drug responses.
In summary, the Ki ras gene, or KRAS gene, is an oncogene involved in cell signaling pathways. Its mutation has been found in various cancers and can influence the prognosis and response to treatment.
