KB cells, also known as Karposi's sarcoma cells, are a cell line that was derived from a human oral tumor. These cells are commonly used in scientific research to investigate various aspects of cell biology, virology, and cancer. The KB cell line was initially established in 1972 and has since become a widely studied model system.
KB cells are an epithelial cell line, meaning that they originate from cells that line the surfaces and cavities of the body. They are derived from a carcinoma of the nasopharynx and possess characteristics of both squamous and adenocarcinoma cells. These cells have been extensively used to study viral infections, particularly the herpes simplex virus.
One of the prominent features of KB cells is their susceptibility to infection by the herpes simplex virus type 1 (HSV-1). Researchers have utilized KB cells to investigate the mechanisms of viral entry, replication, and spread. These studies have contributed to the understanding of viral pathogenesis and have also aided in the development of antiviral drugs.
Additionally, KB cells have been employed to explore the effects of various chemicals, drugs, and environmental factors on cell growth, differentiation, and transformation. Their versatility and ease of maintenance in the laboratory make them a valuable tool for experimental investigations.
Overall, KB cells play a significant role in biomedical research, serving as a valuable model system for studying viral infections, cancer biology, and the effects of various agents on cellular behavior.
