The spelling of the word "Karene" can be explained using IPA phonetic transcription as kəˈren. The first syllable "ka" is pronounced with a schwa sound, represented by the symbol "ə". The second syllable "re" is pronounced with a short "e" sound, represented by the symbol "e". The final "ne" is pronounced with a schwa sound followed by a silent "e", represented by the symbols "ə" and "ˈ" respectively. Overall, the transcription represents a two-syllable word with a stress on the first syllable.