KAOLIN CEPHALIN COAGULATION TIME Meaning and
Definition
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Kaolin Cephalin Coagulation Time (KCCT), also known as Activated Partial Thromboplastin Time (APTT), is a laboratory test used to evaluate the efficiency of the intrinsic coagulation pathway in the blood. It measures the time required for blood to clot upon activation of the intrinsic clotting factors.
The KCCT test involves mixing citrated plasma with Kaolin, a mineral clay, and a partial thromboplastin activator, typically cephalin or phospholipids. These substances facilitate the activation of the intrinsic pathway and promote clot formation. The test measures the time it takes for fibrin strands to form, indicating the functionality of clotting factors such as Factor VIII, IX, XI, and XII.
To conduct the test, a blood sample is collected and treated with a citrate anticoagulant to prevent clot formation. The plasma is separated by centrifugation, and then mixed with the activator and Kaolin. A timer is started once the mixture is activated, and the time is recorded until clot formation occurs.
The KCCT test is commonly used in the diagnosis and monitoring of bleeding disorders, including hemophilia, von Willebrand disease, and abnormalities in clotting factor levels. It provides valuable information about the intrinsic clotting pathway and helps to assess the risk of excessive bleeding or clotting in individuals. Abnormal KCCT results may require further investigation and treatment by medical professionals.
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