JIMPY MICE Meaning and
Definition
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Jimpy Mice:
Jimpy mice refer to a specific strain of laboratory mice that possess a genetic mutation resulting in a distinctive phenotype and certain neurological defects. The term "Jimpy" derives from the British slang meaning "feeble" or "incompetent," reflecting the observed characteristics of these mice. In scientific literature, they are often labeled as "Jp mice."
These mutated mice possess a mutation in the gene encoding proteolipid protein (PLP), an essential component of myelin—a fatty substance that insulates nerve fibers in the central nervous system. Consequently, Jimpy mice exhibit deficits in myelination, leading to dysfunctions in the transmission of nerve impulses. These neurodevelopmental abnormalities manifest in various ways, and affected mice show tremors, ataxia, hindered mobility, and stunted growth.
The specific phenotype of Jimpy mice varies depending on the extent of the PLP mutation and the region of the brain affected. For instance, severe myelination defects in the brain can lead to spastic quadriparesis, while milder mutations result in a milder phenotype characterized by tremors and a wobbly gait.
Due to their well-characterized genetic mutation and neurological abnormalities, Jimpy mice have been extensively employed as animal models in scientific research studies. Researchers often utilize these mice to study the mechanisms underlying myelination disorders and to evaluate potential therapeutic interventions aimed at remedying such pathologies.
Common Misspellings for JIMPY MICE
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