INTRAGENIC SUPPRESSION Meaning and
Definition
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Intragenic suppression refers to a phenomenon in genetics where the effect of a mutation in one gene is counteracted or suppressed by another mutation within the same gene. This type of suppression occurs when the second mutation compensates for the deleterious effects of the initial mutation, therefore restoring the normal function of the gene or its product.
The process of intragenic suppression involves a modification of the original mutation's effect, either by a new mutation occurring at the same site or by alterations elsewhere in the gene sequence. Essentially, the second mutation modifies the protein structure or function in such a way that it can overcome the detrimental effects caused by the initial mutation. This restoration of function can occur through various mechanisms, such as improving protein folding, restoring protein-protein interactions, or enhancing enzymatic activity.
Intragenic suppression is an important concept in understanding genetic diseases and evolution. It highlights the complex interactions within a gene and helps elucidate the relationships between specific mutations and resulting phenotypes. By studying intragenic suppression, researchers can gain insights into the structure-function relationships of genes and proteins. Additionally, it provides valuable information for the development of therapeutic strategies aimed at restoring normal gene function, as the suppression of a mutation may offer potential targets for interventions or the design of gene therapies.
Common Misspellings for INTRAGENIC SUPPRESSION
- untragenic suppression
- jntragenic suppression
- kntragenic suppression
- ontragenic suppression
- 9ntragenic suppression
- 8ntragenic suppression
- ibtragenic suppression
- imtragenic suppression
- ijtragenic suppression
- ihtragenic suppression
- inrragenic suppression
- infragenic suppression
- ingragenic suppression
- inyragenic suppression
- in6ragenic suppression
- in5ragenic suppression
- inteagenic suppression
- intdagenic suppression
- intfagenic suppression
- inttagenic suppression
Etymology of INTRAGENIC SUPPRESSION
The term "intragenic suppression" has a straightforward etymology when broken down into its component parts.
The word "intragenic" consists of two parts, "intra-" and "-genic". "Intra-" is a prefix derived from Latin, meaning "within" or "inside". "-Genic", on the other hand, comes from the combining form "-gen", which is derived from Greek and means "to produce" or "to generate". So, "intragenic" can be understood as "within the gene".
Now, in the context of genetics, the word "suppression" refers to the phenomenon where a mutation is compensated or counteracted either by another mutation within the same gene or by a different mutation in another gene. This concept of suppression refers to the lessening or negation of the effect of a mutation.
