INTERVENING SEQUENCE Meaning and
Definition
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Intervening sequence, also known as an intron, is a term used in genetics and molecular biology to describe a non-coding region of DNA or RNA that interrupts the coding sequence. Specifically, an intervening sequence is a segment of nucleotide sequence that is transcribed into RNA, but does not contribute to the final translated protein product.
Intervening sequences were initially considered as "junk DNA" or genetic remnants with no functional significance. However, further research has revealed their critical role in gene regulation and protein synthesis. They are found in most eukaryotic organisms, including humans, but are absent in prokaryotes such as bacteria.
The process by which intervening sequences are removed from the RNA is known as splicing. During splicing, the introns are precisely excised, and the remaining coding segments, or exons, are then ligated together to form a continuous mRNA molecule. This edited mRNA is subsequently translated into a functional protein.
Intervening sequences play an essential role in increasing proteomic diversity by allowing alternative splicing. This process enables a single gene to encode multiple proteins by differentially including or excluding different exons, contributing to the complexity and diversity of the proteome.
Understanding intervening sequences and their regulation has significant implications for biological research, as alterations in splicing can lead to a variety of genetic disorders and diseases. Research in this field continues to shed light on the intricate mechanisms underlying gene expression and protein synthesis.
Common Misspellings for INTERVENING SEQUENCE
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Etymology of INTERVENING SEQUENCE
The term "Intervening Sequence" originates from the field of molecular biology. Specifically, it refers to a segment of DNA or RNA that is inserted between exons, the coding regions of genes. These intervening sequences are also known as introns.
The etymology of the term can be broken down as follows:
1. Intervening: This word comes from the Latin word "intervenire", which means "to come between". It combines the prefix "inter-" (meaning "between") and the verb "venire" (meaning "to come").
2. Sequence: This word comes from the Latin word "sequi", which means "to follow". It refers to a series of things that come one after another in a specific order.
When combined, "Intervening Sequence" describes a segment of genetic material that comes between other segments, specifically between exons in genes.
