Interstitial nephritis is a condition characterized by inflammation of the kidney's interstitial tissue. The spelling of this medical term can be broken down phonetically as follows: /ɪntə(r)ˈstɪʃ(ə)l nɪˈfraɪtɪs/ (in-tuh-ruh-stish-uhl ni-frahy-tis). The word "interstitial" refers to the area between structures, while "nephritis" means inflammation of the kidneys. This condition typically results from an allergic reaction or exposure to certain medications, and may result in symptoms such as fever, fatigue, and blood in the urine. Prompt diagnosis and treatment can help manage the condition and prevent complications.
Interstitial nephritis refers to a medical condition characterized by inflammation and swelling of the interstitial tissue in the kidneys, which is the area between the renal tubules and the glomeruli. This condition can result in tubular dysfunction and impaired kidney function.
The primary cause of interstitial nephritis is often an immune response triggered by certain medications, such as certain antibiotics (like penicillin or sulfonamides), nonsteroidal anti-inflammatory drugs (NSAIDs), or diuretics. However, other factors like infections, autoimmune diseases, and exposure to certain toxins can also lead to interstitial nephritis.
Symptoms of interstitial nephritis may include decreased urine output, fatigue, fever, nausea, rash, swelling, and blood in the urine. However, some individuals may be asymptomatic or experience mild symptoms.
Diagnosis is typically made through medical history review, physical examination, urine tests (to detect white blood cells or red blood cells in the urine), blood tests (to assess kidney function), and sometimes a kidney biopsy.
Treatment for interstitial nephritis involves identifying and discontinuing the causative agent, if possible. In mild cases, supportive measures like hydration and medication to reduce inflammation may be sufficient. In more severe cases, dialysis or other forms of renal replacement therapy may be necessary.
Prompt diagnosis and management of this condition are crucial to prevent long-term kidney damage or kidney failure. Follow-up care and monitoring are essential to assess kidney function and prevent relapse.
A form in which the interstitial connective tissue is chiefly affected.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The term "interstitial nephritis" derives from two main components: "interstitial" and "nephritis".
1. Interstitial: The word "interstitial" comes from the Latin word "interstitium", which means "small spaces or gaps between things". It refers to the tissue found between the functional units of an organ or structure. In the case of the kidneys, the interstitium is the supportive tissue that surrounds the nephrons, the functional units responsible for filtering and producing urine.
2. Nephritis: The word "nephritis" also originates from Greek and Latin roots. In Greek, "nephros" means "kidney", whereas the Latin suffix "-itis" denotes inflammation. Therefore, "nephritis" essentially means inflammation of the kidneys.
When combined, "interstitial nephritis" describes a specific type of kidney inflammation that primarily affects the interstitial tissue surrounding the nephrons.