INBRED WKY RATS Meaning and
Definition
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Inbred WKY (Wistar Kyoto) rats are a specific strain of laboratory rats that have been bred in a controlled environment over multiple generations to possess specific genetic characteristics. These rats are extensively used in medical and scientific research as a model for studying various physiological and psychological phenomena, especially those related to hypertension, depression, and anxiety disorders.
The term "inbred" refers to the process of maintaining a population by breeding closely related individuals. In the case of WKY rats, inbreeding is conducted to produce consistent genetic traits and minimize genetic variation within the strain. This helps researchers ensure that any observed characteristics or responses in these rats can be attributed to specific genetic factors rather than individual variation.
WKY rats are known to exhibit several traits relevant to human health and behavior. They are commonly used as models for studying hypertension due to their inherent susceptibility to high blood pressure. Furthermore, WKY rats exhibit behavioral characteristics associated with depression and anxiety, such as reduced activity levels, reduced exploratory behavior, and increased immobility in certain tests.
The use of inbred WKY rats allows researchers to conduct experiments and investigations in a controlled manner, helping to reduce unwanted variability and confinements that might arise with genetically diverse populations. Through the study of inbred WKY rats, scientists gain a deeper understanding of the biological and environmental factors that contribute to various health conditions, which can ultimately lead to the development of novel treatments and therapies.
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