INBRED MOUSE STRAINS Meaning and
Definition
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Inbred mouse strains refer to genetically homogeneous populations of laboratory mice that have been bred for many generations through sibling or parent-offspring matings to establish stable and consistent genetic characteristics. These strains are maintained by controlled breeding programs to ensure uniformity within the population and preserve specific inherited traits. Inbred strains are valuable tools in biomedical research as they provide a standardized and predictable model for studying human diseases and genetic variations.
The breeding process involves mating genetically related individuals from the same strain, thereby increasing homozygosity and reducing genetic diversity within the population. This process aims to create mice that are genetically identical at multiple loci, except for any spontaneous or induced genetic mutations that may arise over time.
Due to their homogeneity, inbred mouse strains offer several advantages for scientific investigations. Researchers can replicate experiments across different laboratories, as each mouse within a given inbred strain should have identical genetic backgrounds. This enables the control of genetic variables to study the influence of specific genes on various phenotypic traits or disease susceptibilities. Additionally, inbred strains allow researchers to establish baseline data for comparative studies, facilitating the discovery of novel genetic factors or the evaluation of therapeutic interventions.
Common examples of inbred mouse strains include C57BL/6, BALB/c, and DBA/2, which have been extensively used in biomedical research and have well-documented genetic characteristics and phenotypes. Inbred mouse strains serve as fundamental tools in studying the underlying mechanisms of diseases and developing new therapies, contributing to advancements in human health and medicine.
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