IMMUNOGLOBULIN IDIOTYPE Meaning and
Definition
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Immunoglobulin idiotype refers to the unique set of antigenic determinants found on the variable regions of immunoglobulins (also known as antibodies) produced by B cells. These determinants are specific to each individual B cell clone and are responsible for the diversity of antibodies that can be generated by the immune system.
The immunoglobulin idiotype is comprised of two components: the variable region (V region) and the hypervariable region (or complementarity-determining region, CDR). The V region is responsible for the recognition and binding of specific antigens, while the CDRs are the most variable parts of the V region and play a crucial role in antigen recognition and binding.
The idiotype of an immunoglobulin is determined by the unique amino acid sequence of its V region and CDRs. This sequence is encoded by genes that undergo somatic recombination and mutation, leading to a vast repertoire of antibodies that can recognize and bind a wide range of antigens.
The knowledge of immunoglobulin idiotype is especially important in the field of immunology and immunotherapy. It allows researchers and clinicians to study and target specific B cell clones or antibodies based on their unique idiotype, providing insights into immune responses, autoimmunity, and the development of targeted therapies for cancer and autoimmune diseases.
In summary, immunoglobulin idiotype refers to the unique antigenic determinants found on the variable regions of antibodies, which are responsible for the diversity of antibodies produced by the immune system.
Common Misspellings for IMMUNOGLOBULIN IDIOTYPE
- ummunoglobulin idiotype
- jmmunoglobulin idiotype
- kmmunoglobulin idiotype
- ommunoglobulin idiotype
- 9mmunoglobulin idiotype
- 8mmunoglobulin idiotype
- inmunoglobulin idiotype
- ikmunoglobulin idiotype
- ijmunoglobulin idiotype
- imnunoglobulin idiotype
- imkunoglobulin idiotype
- imjunoglobulin idiotype
- immynoglobulin idiotype
- immhnoglobulin idiotype
- immjnoglobulin idiotype
- imminoglobulin idiotype
- imm8noglobulin idiotype
- imm7noglobulin idiotype
- immuboglobulin idiotype
- immumoglobulin idiotype
Etymology of IMMUNOGLOBULIN IDIOTYPE
The etymology of the word "Immunoglobulin Idiotype" can be broken down as follows:
1. Immunoglobulin: The word "immunoglobulin" is derived from two parts - "immuno" and "globulin".
- "Immuno" comes from the Latin word "immunis", meaning "exempt or free". It refers to the immune system's ability to protect the body by recognizing and eliminating foreign substances.
- "Globulin" is a type of protein found in the blood plasma. It is derived from the Latin word "globus", meaning "a rounded body or sphere".
Therefore, "immunoglobulin" refers to a group of proteins produced by the immune system as a response to foreign substances (antigens) and playing a vital role in immune responses.
