IMMUNOGLOBULIN ALLOTYPE Meaning and
Definition
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Immunoglobulin Allotype refers to the genetic variants of immunoglobulins (antibodies) that exist among individuals within a species. Antibodies are proteins produced by the body's immune system to help combat foreign substances, such as pathogens or antigens.
The immunoglobulin allotype is determined by the genetic makeup of an individual, specifically variations in the genes that code for immunoglobulin heavy chains (IgH), light chains (IgL), or both. These genetic variations can result in differences in the amino acid sequences of the antibody molecules between individuals.
Immunoglobulin allotypes are classified based on the presence or absence of specific genetic markers, known as allotype markers, which are usually detected by serological or molecular techniques. These markers are determined by the inheritance of certain alleles from each parent.
The different immunoglobulin allotypes observed in a population contribute to the overall immune diversity within that population. They can affect the efficacy of antibody responses, susceptibility to infections, and responses to vaccination. Additionally, allotypes have been associated with certain diseases and immune disorders.
Understanding immunoglobulin allotypes allows researchers and clinicians to examine the genetic basis of antibody diversity and tailor immunotherapies or vaccinations to individuals with specific allotypes. It also aids in population studies and classification of antibodies based on the serological or molecular detection of allotype markers.
Common Misspellings for IMMUNOGLOBULIN ALLOTYPE
- ummunoglobulin allotype
- jmmunoglobulin allotype
- kmmunoglobulin allotype
- ommunoglobulin allotype
- 9mmunoglobulin allotype
- 8mmunoglobulin allotype
- inmunoglobulin allotype
- ikmunoglobulin allotype
- ijmunoglobulin allotype
- imnunoglobulin allotype
- imkunoglobulin allotype
- imjunoglobulin allotype
- immynoglobulin allotype
- immhnoglobulin allotype
- immjnoglobulin allotype
- imminoglobulin allotype
- imm8noglobulin allotype
- imm7noglobulin allotype
- immuboglobulin allotype
- immumoglobulin allotype
Etymology of IMMUNOGLOBULIN ALLOTYPE
The word "immunoglobulin" is a combination of the Latin word "immunis" which means "free" or "exempt from" and "globulin" which refers to a class of proteins found in the blood. It was first coined in 1906 by German scientist Paul Ehrlich to describe the class of proteins responsible for the immune response.
The term "allotype" is derived from the Greek word "allos" meaning "other" or "different" and "typos" meaning "type" or "pattern". In the context of immunoglobulins, "allotype" refers to the genetic variants or alleles that individuals possess within a particular immunoglobulin class or subclass.
Therefore, the term "immunoglobulin allotype" refers to the genetic variants or alleles present within a specific class or subclass of immunoglobulins.
