How Do You Spell IDURONATE?

Pronunciation: [ˈa͡ɪdjʊ͡əɹˌɒne͡ɪt] (IPA)

The word "iduronate" is a biochemical term used to describe a type of sugar molecule. Its spelling reflects its pronunciation, with the emphasis on the second syllable: /aɪˈdjʊərəneɪt/. The first syllable is pronounced as "eye," followed by "dj" which represents the "j" sound in the word "joke." The "u" symbol represents the "oo" sound in "moon," and the syllable "rate" is pronounced as "rayt." The IPA phonetic transcription helps to clarify the pronunciation of the word for those unfamiliar with its spelling.

IDURONATE Meaning and Definition

1. Iduronate is a chemical compound and a derivative of glucose, classified as a monosaccharide. It consists of a six-membered ring structure with five carbon atoms and one oxygen atom. Iduronate is a carboxylic acid derivative, with a carboxyl group at the carbon atom adjacent to the oxygen atom.

   Iduronate is often found attached to other molecules, such as proteins or glycosaminoglycans (GAGs), which are complex sugars. GAGs are essential components of connective tissues, such as cartilage and the extracellular matrix, and play a crucial role in maintaining their structural integrity. Iduronate residues form important components of specific GAGs, including dermatan sulfate and heparan sulfate.

   Deficiencies in enzymes involved in the metabolism of iduronate can lead to various genetic disorders known as mucopolysaccharidoses (MPSs). These disorders are characterized by the buildup of certain GAGs in cells and tissues, leading to cellular dysfunction and the progressive deterioration of multiple organ systems.

   Iduronate is also used in laboratory research as a building block for the synthesis of various compounds, such as drugs or chemical probes, with potential therapeutic or investigational applications. Its chemical structure and functional properties make it a valuable tool for studying the biology and biochemistry of GAGs and their involvement in various physiological and pathological processes.

Common Misspellings for IDURONATE

• uduronate
• jduronate
• kduronate
• oduronate
• 9duronate
• 8duronate
• isuronate
• ixuronate
• icuronate
• ifuronate
• iruronate
• ieuronate
• idyronate
• idhronate
• idjronate
• idironate
• id8ronate
• id7ronate
• idueonate
• idudonate

Etymology of IDURONATE

The word "iduronate" is derived from the term "iduronic acid". The etymology of "iduronic acid" can be traced back to its discovery by a Japanese biochemist named Minoru Shindo in 1955. He isolated the acid from the urine of patients suffering from Hurler syndrome, a rare genetic disorder.

The name "iduronic" was coined from the initials IDU, symbolizing Ido-uronic acid, the full name of the compound at that time. "Ido" refers to idose, a type of sugar, which combines with uronic acid to form iduronic acid.

Over time, the name evolved to "iduronate" to indicate that iduronic acid is actually the anionic form of the compound. This nomenclature change is consistent with the naming convention used for various types of sugars and their corresponding anionic forms.