IDOASE Meaning and
Definition
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The term "IDOase" refers to an enzyme known as indoleamine-2,3-dioxygenase (IDO), which plays a pivotal role in regulating the immune system. IDOase is derived from the combination of the abbreviation "IDO" and the suffix "-ase" which denotes an enzyme.
IDOase acts as a catalyst for the conversion of the amino acid tryptophan into kynurenine, an important step in the metabolism of tryptophan. In viral infections, IDOase is activated as a defense mechanism by immune cells such as macrophages and dendritic cells, leading to a significant depletion of tryptophan levels in the local environment. Consequently, this depletion inhibits the replication of certain viruses, ultimately curtailing their spread throughout the body.
Furthermore, IDOase is also involved in the modulation of the immune response, particularly in the context of immune tolerance and inflammation. Its activity can regulate the balance between immune activation and suppression. By metabolizing tryptophan into kynurenine, IDOase promotes the production of immunosuppressive molecules that modulate the function of various immune cells, including T cells. This modulation helps prevent excessive immune responses, which could lead to tissue damage.
IDOase has gained considerable interest in medical research due to its potential therapeutic implications. In certain diseases, such as cancer and autoimmune disorders, IDOase expression is dysregulated, leading to immune evasion or exaggerated immune responses. As a result, targeting IDOase activity is being explored as a strategy for immunotherapy and the development of novel treatments.
Common Misspellings for IDOASE
- udoase
- jdoase
- kdoase
- odoase
- 9doase
- 8doase
- isoase
- ixoase
- icoase
- ifoase
- iroase
- ieoase
- idiase
- idkase
- idlase
- id0ase
- id9ase
- idozse
- idosse
- idowse
Etymology of IDOASE
The word "IDOase" is derived from the enzyme IDO (Indoleamine 2,3-dioxygenase) and the suffix "-ase", which is commonly used to denote an enzyme. The term "IDO" originates from its function of catalyzing the oxidative cleavage of the indole ring of the amino acid tryptophan. "IDO" itself is an abbreviation of "indoleamine" and "2,3-dioxygenase", emphasizing its role in the degradation of indoleamine compounds. Therefore, the word "IDOase" is simply formed by combining the abbreviation "IDO" with the suffix "-ase" to indicate the enzyme's identity and function.
