How Do You Spell HOWELL JOLLY BODIES?

Pronunciation: [hˈa͡ʊɛl d͡ʒˈɒli bˈɒdɪz] (IPA)

Howell Jolly Bodies are small round structures found in red blood cells, usually seen when the spleen is not working correctly. The spelling of this medical term uses the International Phonetic Alphabet (IPA) phonetic transcription. The phonetic transcription is /haʊl ˈdʒɒli ˈbɒdiz/. The "ow" sound in Howell is pronounced like the "ou" in "loud." The "j" in Jolly is pronounced like the "j" in "jump." The stress is on the first syllable of Jolly, and the "y" is pronounced like the "i" in "pigeon."

HOWELL JOLLY BODIES Meaning and Definition

1. Howell-Jolly bodies are microscopic structures that can be observed within red blood cells under certain conditions. They are named after William Henry Howell and Justin Marie Jolly, who first described them in the early 20th century. Howell-Jolly bodies are characterized as small, round, basophilic inclusions that appear as compact dots within the erythrocytes when stained with a specific dye.

   The presence of Howell-Jolly bodies is typically abnormal and is often associated with various underlying medical conditions. Normally, red blood cells undergo a process known as pitting, where any nuclear remnants are removed before the cells are released into circulation. However, when this process is impaired due to certain factors, such as splenectomy (removal of the spleen) or a dysfunctional spleen, Howell-Jolly bodies can emerge.

   The appearance of Howell-Jolly bodies can serve as an indicator of impaired splenic function and can be seen in conditions like sickle cell disease, hemolytic anemias, megaloblastic anemias, and other conditions associated with decreased or absent splenic function. Howell-Jolly bodies are commonly used as a marker for evaluating the function of the spleen and can be observed through a blood smear examination.

   In summary, Howell-Jolly bodies are small, round, basophilic inclusions found within red blood cells. Their presence is often associated with conditions that impair normal spleen function and can provide important diagnostic information.

2. Jolly bodies.

   A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

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