The spelling of "Histidine Specific tRNA" can be a bit tricky due to the combination of different sounds. "Histidine" is pronounced as /hɪs.tɪ.diːn/, with the stress on the second syllable. "Specific" is pronounced as /spəˈsɪfɪk/. The word "tRNA" stands for "transfer RNA" and is pronounced as /tiː ɑːr ɛn eɪ/. Overall, the correct pronunciation of this word is /hɪs.tɪ.diːn spəˈsɪfɪk tiː ɑːr ɛn eɪ/, with stress on the second syllable of "histidine" and the first syllable of "specific".
Histidine-specific tRNA refers to a type of transfer RNA (tRNA) molecule that specifically recognizes and transports the amino acid histidine during protein synthesis. tRNA molecules are essential components of the translation process, where they serve as adapters between the genetic code carried by mRNA and the amino acids that are assembled into a protein chain.
Histidine-specific tRNA molecules have a distinct three-dimensional structure that allows them to selectively bind histidine, distinguishing it from other amino acids. This specific tRNA molecule recognizes a particular nucleotide sequence, known as the anticodon, within the mRNA molecule. The anticodon on the tRNA is complementary to the codon on the mRNA, ensuring accurate pairing and delivery of histidine to the growing protein chain.
During translation, histidine-specific tRNA molecules are charged, or activated, by specific enzymes called aminoacyl-tRNA synthetases. These enzymes covalently attach the appropriate amino acid to the tRNA molecule, in this case, histidine, effectively "charging" it for delivery to the ribosome.
Once the histidine-specific tRNA is loaded with histidine, it enters the ribosome, the cellular machinery responsible for protein synthesis. The ribosome recognizes the codon on the mRNA molecule and pairs it with the corresponding anticodon on the tRNA, ensuring the correct insertion of histidine into the growing protein chain.
In summary, histidine-specific tRNA is a crucial component of the translation process, facilitating the accurate incorporation of the amino acid histidine into proteins.