HEXAMETHYLPHOSPHORIC TRIAMIDE Meaning and
Definition
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Hexamethylphosphoric triamide (HMPA) is a chemical compound with the molecular formula (CH3)3PN(CH3)2. It is an organophosphorus compound featuring an amide functional group with three methyl groups attached to a phosphorus atom. HMPA is a colorless liquid with a faint odor and is miscible in a variety of organic solvents such as alcohols, ethers, and hydrocarbons.
In terms of its chemical properties, HMPA is known for its strong ability to solvate metal ions and other polar compounds. It acts as a coordinating solvent or a ligand, enhancing reactions involving coordination compounds. HMPA can effectively solvate bulky metal cations and stabilize transition states by reducing the dielectric constant, making it an essential reagent in various synthetic reactions. Its high boiling point and low acidity make it a useful alternative to other polar solvents like dimethyl sulfoxide (DMSO).
HMPA has found significant applications in organic synthesis, particularly as a solvent in reactions involving metal reagents, alkali metals, metal amides, and other strongly basic or reducing substances. It has been used in reactions such as the generation and deprotonation of enolates, formation of Grignard reagents, and different metal-mediated transformations.
It is important to note that HMPA poses potential health hazards due to its toxic nature. It has been classified as a reproductive toxicant, and exposure to this compound should be handled with caution, employing appropriate safety measures.
Common Misspellings for HEXAMETHYLPHOSPHORIC TRIAMIDE
- gexamethylphosphoric triamide
- bexamethylphosphoric triamide
- nexamethylphosphoric triamide
- jexamethylphosphoric triamide
- uexamethylphosphoric triamide
- yexamethylphosphoric triamide
- hwxamethylphosphoric triamide
- hsxamethylphosphoric triamide
- hdxamethylphosphoric triamide
- hrxamethylphosphoric triamide
- h4xamethylphosphoric triamide
- h3xamethylphosphoric triamide
- hezamethylphosphoric triamide
- hecamethylphosphoric triamide
- hedamethylphosphoric triamide
- hesamethylphosphoric triamide
- hexzmethylphosphoric triamide
- hexsmethylphosphoric triamide
- hexwmethylphosphoric triamide
- hexqmethylphosphoric triamide
Etymology of HEXAMETHYLPHOSPHORIC TRIAMIDE
The etymology of the word "Hexamethylphosphoric Triamide" can be broken down as follows:
1. Hexa-: This prefix comes from the Greek word "hexa", meaning "six". It indicates that the molecule contains six of a particular element or group.
2. Methyl-: This prefix comes from the Greek word "méthylē", meaning "wine" or "spirits". In organic chemistry, it refers to a group containing one carbon atom bonded to three hydrogen atoms.
3. Phosphoric: This term is derived from the element phosphorus (P), which comes from the Greek word "phosphoros", meaning "light-bringing". It denotes that the molecule contains a phosphorus atom.
4. Tri-: This prefix comes from the Latin word "tres", meaning "three". It indicates that the molecule contains three of a particular element or group.
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