HEME CONTROLLED REPRESSOR Meaning and
Definition
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Heme Controlled Repressor (HCR) is a type of transcription factor protein that regulates gene expression in response to changes in cellular heme concentration. HCR acts as a repressor, meaning it inhibits the transcription of specific target genes.
Heme is an iron-containing molecule found in hemoglobin and various enzymes, playing a crucial role in oxygen transport and metabolism. HCR senses the intracellular heme levels and modulates gene expression accordingly. When heme concentration is low, HCR is activated and binds to DNA regions called operator sites located near target genes. This binding prevents RNA polymerase from binding to the promoter region, therefore suppressing transcription and reducing the synthesis of proteins involved in heme production or utilization.
HCR regulates genes involved in heme biosynthesis and heme-dependent metabolic pathways. By tightly controlling the expression of these genes, HCR helps maintain cellular heme homeostasis, ensuring an adequate supply of heme for essential cellular functions. When heme concentrations are sufficient or in excess, heme molecules can bind to HCR, causing its conformational change and detaching it from the operator sites. This releases the repression and allows gene transcription to proceed, leading to increased production of proteins involved in heme synthesis and utilization.
In summary, Heme Controlled Repressor is a transcription factor protein that senses cellular heme levels and regulates gene expression accordingly to maintain heme homeostasis. It acts as a repressor by binding to operator sites near target genes under low heme conditions, preventing their transcription, and releasing repression when heme concentrations are sufficient or high.
Common Misspellings for HEME CONTROLLED REPRESSOR
- geme controlled repressor
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- yeme controlled repressor
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- heke controlled repressor
- heje controlled repressor
- hemw controlled repressor
- hems controlled repressor
- hemd controlled repressor
- hemr controlled repressor
- hem4 controlled repressor
