Helper T cells, also known as CD4+ T cells, are a type of white blood cell that plays a crucial role in the immune system. The spelling of this term can be explained using International Phonetic Alphabet (IPA) transcription as /ˈhɛlpər ti sɛlz/. The "h" at the beginning is silent, and the "e" is pronounced as a short "eh" sound. The "t" in T cells is pronounced as a glottal stop, and the "s" is pronounced as a voiced "z" sound. Overall, this term uses common English spelling conventions for the pronunciation of each letter.
Helper T cells, also known as CD4+ T cells, are a type of white blood cell that play a critical role in the immune response of the body. They are called "helper" cells because they assist other immune cells in their functions by providing necessary signals and support.
Helper T cells are primarily activated by recognizing antigens on the surface of pathogens or foreign substances. Once activated, they release chemical signals called cytokines that stimulate and coordinate the immune response. These cytokines direct other immune cells to perform their specific tasks in fighting infections or destroying abnormal cells.
Helper T cells have several subsets with different functions. The two main subsets are called TH1 and TH2 cells. TH1 cells primarily activate immune responses against intracellular pathogens, such as viruses and some bacteria. On the other hand, TH2 cells are involved in coordinating immune responses against extracellular pathogens, such as parasites, and in promoting the production of antibodies by B cells.
Helper T cells also play a crucial role in regulating the immune response to prevent it from becoming excessive. They interact with regulatory T cells (Tregs) to maintain immune balance and prevent the immune system from attacking the body's own cells.
Deficiencies or dysfunctions in helper T cell populations can lead to immune disorders, such as HIV/AIDS, where the virus specifically targets and destroys CD4+ T cells, compromising the immune system's ability to fight infections.