HELIX TURN HELIX MOTIF Meaning and
Definition
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The helix-turn-helix motif is a DNA-binding structural motif commonly found in many DNA-binding proteins. It is characterized by the presence of two alpha-helices connected by a short loop or turn. This motif enables proteins to interact with specific DNA sequences and regulate gene expression.
The first alpha-helix, known as the recognition helix, contains key amino acid residues that make specific contacts with the DNA sequence. This recognition helix facilitates the recognition and binding of the protein to a specific DNA sequence through hydrogen bonding and hydrophobic interactions. The second alpha-helix, known as the stabilizing helix, contributes to the overall stability and structure of the motif.
The loop or turn connecting the two alpha-helices allows flexibility and positioning of the recognition helix for optimal DNA binding. Different protein families may exhibit variations in the length and composition of this loop region, leading to different binding specificities and affinities.
The helix-turn-helix motif is often involved in DNA-protein interactions such as transcription factor binding, DNA repair, and gene regulation. It plays a crucial role in controlling gene expression by either activating or repressing the transcription of target genes.
Understanding the helix-turn-helix motif and its variations is essential in deciphering the mechanisms of DNA-protein recognition and interactions, as well as providing insights into the regulation of fundamental biological processes.
Common Misspellings for HELIX TURN HELIX MOTIF
- gelix turn helix motif
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- hslix turn helix motif
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- hrlix turn helix motif
- h4lix turn helix motif
- h3lix turn helix motif
- hekix turn helix motif
- hepix turn helix motif
- heoix turn helix motif
- helux turn helix motif
- heljx turn helix motif
- helkx turn helix motif
- helox turn helix motif
- hel9x turn helix motif
