HARVEY MURINE SARCOMA VIRUS Meaning and
Definition
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Harvey murine sarcoma virus (Ha-MuSV) is a retrovirus that belongs to the oncogenic subgroup of retroviruses, capable of inducing tumors and cancers in animals. The virus was first discovered in mice and has been extensively studied as a model for understanding the molecular mechanisms of cancer development and progression.
Ha-MuSV is named after the scientist Michael Harvey, who identified the virus. It is classified as an RNA virus, which means its genetic material is composed of RNA instead of DNA. The virus enters host cells and utilizes the enzyme reverse transcriptase to convert its RNA genome into a DNA form that can be integrated into the host cell's genetic material.
Infection with Ha-MuSV can lead to the formation of sarcomas, which are cancerous tumors arising from connective tissues such as bone, muscle, or cartilage. The virus possesses an oncogene called v-Ha-ras, which contributes to its tumorigenic properties by promoting uncontrolled cell growth and division. The v-Ha-ras protein encoded by the virus acts as a potent activator of cellular signaling pathways involved in cell proliferation and survival.
Studies utilizing Ha-MuSV have provided valuable insights into the molecular mechanisms of cancer and have paved the way for the development of targeted therapies for various forms of human cancer. The virus continues to be an important research tool for scientists studying oncogenesis and tumor biology.
Common Misspellings for HARVEY MURINE SARCOMA VIRUS
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