Harmine is a psychoactive compound found in several plants such as Banisteriopsis caapi, Peganum harmala, and Passiflora incarnata. Its spelling is pronounced /ˈhɑːmɪn/ in IPA phonetic transcription. The word "har-", pronounced /hɑː/, represents the first syllable and is consistent with the pronunciation of the word "hard". The "-mine" ending, pronounced /mɪn/, is the same as the suffix used in many other alkaloids such as cocaine and morphine, which are also derived from plant sources.
Harmine is a naturally occurring chemical compound that belongs to the class of harmala alkaloids. It is derived from various plants, most notably the Banisteriopsis caapi vine, which is commonly used in traditional South American medicine and spiritual practices such as Ayahuasca ceremonies. Harmine is also found in smaller quantities in other plants, including Peganum harmala.
Chemically, harmine is a beta-carboline alkaloid with a molecular formula of C13H12N2O. It is characterized by its yellowish color and crystalline structure. It possesses psychoactive properties and has been studied for its potential therapeutic effects on the human brain.
Harmine interacts with the central nervous system by acting as a reversible inhibitor of monoamine oxidase enzymes, particularly the MAO-A subtype. These enzymes are responsible for breaking down neurotransmitters such as serotonin and dopamine. By inhibiting MAO-A, harmine increases the levels of these neurotransmitters in the brain, affecting mood, cognition, and perception.
The compound has gained attention in the field of pharmacology and neuroscience due to its potential as a treatment for various neurodegenerative disorders. Some research suggests that harmine may exhibit neuroprotective properties and could have a positive impact on conditions such as Alzheimer's disease and Parkinson's disease. Additionally, harmine has also been investigated for its anti-cancer, anti-inflammatory, and antioxidant effects.
Despite its potential therapeutic benefits, harmine should be used with caution due to its psychoactive nature. It is important to note that the consumption of harmine-containing plants or isolated harmine should only be done under proper supervision and in accordance with local laws and regulations.
An alkaloid derived, with harmaline, from the seeds of the wild rose.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "Harmine" derives from the plant species Peganum harmala, commonly known as Syrian rue. The term "harmine" specifically refers to one of the main active compounds found in this plant's seeds. The etymology of "harmine" can be traced back to the Arabic word "harmal", which refers to the plant itself. This term was then modified into Latin as "harmala". From there, it evolved into different variations such as "harmaline" and "harmine", used to describe specific alkaloids found in the plant.